□他の発現解析技術との比較

遺伝子発現解析の手法は多くあり、それぞれに利点があります。 CAGE-seqと主な遺伝子発現解析の違いは、CAGE-seqがゲノムワイドに転写開始点をより正確に同定できるという点にあります。

CAGE-seqでは、プロモーター領域の詳細な解析ができるため、特定遺伝子の発現を、制御に関与したプロモーターごとに分けて解析することが可能となり、転写のシグナル伝達のカスケードを明らかにするなど、新しい視点に立ったゲノムアノテーションが可能になります。

□FANTOM主要論文

• FANTOM Consortium et al, A promoter level mammalian expression atlas, Nature, 507(7493), 462-470 (2014)
• Andersson R et al, An atlas of active enhancers across human cell types and tissues, Nature, 507(7493), 455-461 (2014)

□その他

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